Tuesday, June 25, 2013

Angelina Jolie, UNHCR Envoy, Urges World To End Rape In War

UNITED NATIONS ? Angelina Jolie made her debut before the U.N.'s most powerful body as a special envoy for refugees Monday and urged the world's nations to make the fight against rape in war a top priority.

The actress told the Security Council that "hundreds of thousands ? if not millions ? of women, children and men have been raped in conflicts in our lifetimes."

Jolie, a goodwill ambassador for the U.N. high commissioner for refugees, said the Security Council has witnessed 67 years of wars and conflict since it was established "but the world has yet to take up warzone rape as a serious priority."

"You set the bar," she told the council. "If the ... council sets rape and sexual violence in conflict as a priority it will become one and progress will be made. If you do not, this horror will continue."

British Foreign Secretary William Hague, who presided over the meeting, stressed that "in conflicts in nearly every corner of the globe, rape is used systematically and ruthlessly, in the almost certain knowledge that there will be no consequences for the perpetrators."

Soon after Jolie spoke, the council adopted a legally-binding resolution demanding the complete and immediate cessation of all acts of sexual violence by all parties to armed conflict. It noted that sexual violence can constitute a crime against humanity and a contributing act to genocide, called for improved monitoring of sexual violence in conflict, and urged the U.N. and donors to assist survivors.

It was the broadest resolution adopted by the council on the sexual violence in conflict. Hague said Britain plans to follow-up by convening a global gathering during the annual General Assembly meeting of world leaders in September to keep up the pressure for action.

Hague said at a discussion later at the Ford Foundation that his prime motivation for pressing for global action against sexual violence was the 1990s war in Bosnia, partly because of an adviser but also because of Jolie's 2011 film, "In the Land of Blood and Honey," about former lovers who end up on the opposite sides of the conflict. He said he arranged the film's British premiere at the Foreign Office and has been campaigning with Jolie since then, including a visit to Congo in March, "to move the stigma and the shame from the victim to the perpetrator."

"The time has come for the world to take a strong and determined stand to make clear that the systematic use of rape as a weapon is not acceptable in the modern world and our objective is to change the entire global attitude to these issues," Hague said.

Getting the whole world talking about sexual violence in conflict and the need to punish perpetrators not victims "will shift attitudes ? maybe over a period of years, but we have begun," he said.

Jolie, who has traveled extensively in her role as goodwill ambassador, recalled several of the survivors she had met ? the mother of a five-year-old girl raped outside a police station in Goma in eastern Congo, and a Syrian woman she spoke to in Jordan last week who asked to hide her name and face "because she knew that if she spoke out about the crimes against her she would be attacked again, and possibly killed."

"Let us be clear what we are speaking of: Young girls raped and impregnated before their bodies are able to carry a child, causing fistula," Jolie said, referring to an injury caused by violent rapes that tear apart the flesh separating the bladder and rectum from the vagina, leaving the girls unable to control their bowels or bladder.

She continued: "Boys held at gunpoint and forced to sexually assault their mothers and sisters. Women raped with bottles, wood branches and knives to cause as much damage as possible. Toddlers and even babies dragged from their homes, and violated."

Zainab Hawa Bangura, the U.N. special envoy on sexual violence in conflict, told the council that two weeks ago she visited Bosnia where an estimated 50,000 women were victims of rape and other forms of sexual violence during the war, but only a handful of perpetrators have been prosecuted.

Later, at the Ford Foundation, she said that on an African trip with Hague, she visited the village of Mambasa in eastern Congo's Ituri district where 11 babies aged 6 to 12 months had been raped, 59 children aged 1 to 3 years old had been raped and 182 girls aged 5 to 15 years old had been raped.

"Who will rape a baby?," Bangura asked. "It means you want to wipe the community away. That's the only explanation you can have."

Jolie pleaded with the Security Council ? and all countries ? to implement the resolution and not let the issue drop.

"Meet your commitments, debate this issue in your parliaments, mobilize people in your countries, and build it into all your foreign policy efforts," she urged. "Together, you can turn the tide of global opinion, shatter impunity and finally put an end to this abhorrence."

U.N. Secretary-General Ban Ki-moon paid tribute to Jolie for being the voice of millions forced to flee their homes "and now for the many survivors of wartime rape whose bodies have been used as battlegrounds."

He called on all leaders to apprehend and prosecute perpetrators "and be part of a global coalition of champions determined to break this evil."

Also on HuffPost:

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Source: http://www.huffingtonpost.com/2013/06/24/angelina-jolie-unhcr-envoy_n_3491103.html

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Apple Releases iOS 7 Beta 2 With Support For iPads

Apple Releases iOS 7 Beta 2 With Support For iPads

Apple has released beta 2 of its mobile OS for developers just two weeks after WWDC where the company showed off iOS 7. This release also supports iPads and iPad minis.

Apple Releases iOS 7 Beta 2 With Support For iPads

Other than that, there's a new Voice Memos app, which seems to have been inspired by the Flip camera. Siri can now yammer at you in a female or male voice, too. The Reminders app, panoramic camera UI and the addition of avatars in group iMessages, along with general bug fixes and performance tweaks round out this version. Unfortunately the stock app icons also appear to be unchanged. Let us know if you notice anything else. [Apple]

Source: http://gizmodo.com/apple-releases-ios-7-beta-2-with-support-for-ipads-559863719

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Monday, June 24, 2013

Grief-stricken Zito helps Giants beat Marlins

By JANIE McCAULEY

AP Baseball Writer

Associated Press Sports

updated 7:42 p.m. ET June 22, 2013

SAN FRANCISCO (AP) - Even after his father's passing this week, Barry Zito planned to pitch on turn Saturday just three days later.

And pitch he did.

Zito tossed seven impressive innings with a heavy heart to keep the San Francisco Giants in the game, and they won it 2-1 on Hector Sanchez's bloop single with one out in the 11th inning to snap a nine-game home losing streak to the Miami Marlins.

"I'm doing all right," Zito said. "I went out there today and was able to keep my stuff down for the most part. ... I wanted to stay on turn and help the ballclub the best I can. It was good to be able to go out there and throw. I just try to minimize distractions and take the mound regardless of what it is. Some things are a little heavier than others."

Giants right fielder Hunter Pence made a diving catch to rob Placido Polanco of a likely go-ahead single to end the 11th as Miami left runners on first and second in back-to-back innings. The Giants beat the Marlins at home for the first time since July 28, 2010.

Mike Dunn (2-2) allowed Gregor Blanco's infield single to start the 11th. Ryan Webb relieved and gave up Buster Posey's infield single. Pence was intentionally walked and Sanchez singled to left for his third game-ending hit.

Blanco hit a tying double in the fifth for the Giants.

Sergio Romo struck out Giancarlo Stanton to end the eighth but yielded Polanco's leadoff single in the 10th. After a strikeout of Jeff Mathis, Javier Lopez relieved and gave up a base hit to pinch-hitter Greg Dobbs. Sandy Rosario (2-0) entered and struck out Justin Ruggiano and Ed Lucas, pumping his fists when the inning ended.

Lucas hit his first career home run as the Marlins grabbed a quick lead on Zito in the first, and added a pair of singles. He traded a signed bat for the souvenir home run ball.

"I think some kid caught it in the outfield," Lucas said. "They were yelling at him to throw it back. He held onto it. It was a pretty good decision for him."

Zito took the mound following the Wednesday death of his dad, Joe, at age 84. The left-hander spent that day in Southern California.

"Barry's the ultimate professional, but when you lose a family member, especially a parent, I can't imagine what he was going through," Posey said. "He stuck to his routine and gave us a great performance."

The pitcher told Bruce Bochy he planned to stay on schedule and make his Saturday start - and the sellout crowd of 41,683 showed its support with a roaring standing ovation when Zito walked off the mound in the seventh to end his outstanding day.

Zito allowed one run on six hits, struck out five and walked two in a second straight no-decision.

The Marlins' nine-game winning streak at AT&T Park was the club's longest in franchise history against any opponent.

The nine victories in a row in San Francisco tied the second-longest unbeaten run in the team's waterfront ballpark with the Padres from July 2, 1995, to Sept. 16, 1996. The Los Angeles Dodgers won 11 in a row in San Francisco from Aug. 19, 2006, to July 15, 2007.

Giants shortstop Brandon Crawford was 0 for 4 while returning to the lineup after missing three games with two sprained fingers on his right hand.

The Giants missed a chance in the first on Blanco's baserunning blunder. He and Marco Scutaro started the inning with consecutive singles, then Posey flied out to shallow center and Marcell Ozuna threw out Blanco at second when he was caught off the bag after taking an early jump.

In the second, Juan Perez reached on a two-out walk only to be picked off at first. Scutaro grounded into an inning-ending double play in the third for yet another squandered chance. Perez was thrown out at the plate in the fifth on a squeeze attempt.

In the fifth, Blanco was credited with an RBI double after a fan reached over the 20-foot wall in right field and snatched the ball on a high bounce. Blanco was then moved to third, as it is the umpires' discretion to determine where they thought the baserunner would have ended up without the interference.

Marlins manager Mike Redmond received his first career ejection as a skipper for arguing the ruling.

"I thought initially it was a ground-rule double. He called fan interference," Redmond said. "I just didn't think Barry Zito would have scored from first."

Bochy, meanwhile, thought Blanco might have had an inside-the-park homer otherwise.

The 31-year-old Lucas was a career minor leaguer who logged 925 games while trying to break into the big leagues, including six of his 10 minor league years at Triple-A. He finally got his shot on May 30 - eight days after turning 31 - when he made his major league debut as a defensive replacement in the ninth inning against Tampa Bay.

Marlins starter Jacob Turner, facing the Giants for the first time in his career, hung tough in his duel with Zito. Turner singled in the fifth for his first major league hit.

A day after going 1 for 14 with runners in scoring position, San Francisco didn't convert in such situations until Posey's hit - putting the Giants at 4 for 25 in the first three games.

NOTES: Stanton had a 10-game hitting streak against San Francisco snapped. ... Giants OF Andres Torres hobbled through the clubhouse with his right knee wrapped in ice a day after injuring it on a slide trying to stretch a double into a triple. He was still sore and had swelling in the knee, but improved enough that Bochy considered him a possibility to play Sunday's series finale. ... Marlins Spanish radio voice, Felo Ramirez, celebrated his 90th birthday. ... Redmond had one ejection during his 13-year playing career.

? 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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Sunday, June 23, 2013

Aiming To Disrupt Payday Lending, Andreessen-Backed LendUp Now Offers Instant Online And Mobile Loans

Screen shot 2013-06-21 at 12.03.03 PMY Combinator-incubated LendUp launched in October with backing from Kleiner Perkins, Andreessen Horowitz, Google Ventures, Kapor Capital and others, to bring a fresh solution to an old problem: You have to pay your bills now, but you don't have the money to pay them. Rather than turn to predatory lenders and banks, with their high interest rates, borrow money from friends or cover your eyes and hope they go away, what do you do?

Source: http://feedproxy.google.com/~r/Techcrunch/~3/JgVSgMMUbrw/

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Sunday, May 5, 2013

Human brain cells developed in lab, grow in mice

May 3, 2013 ? A key type of human brain cell developed in the laboratory grows seamlessly when transplanted into the brains of mice, UC San Francisco researchers have discovered, raising hope that these cells might one day be used to treat people with Parkinson's disease, epilepsy, and possibly even Alzheimer's disease, as well as and complications of spinal cord injury such as chronic pain and spasticity.

"We think this one type of cell may be useful in treating several types of neurodevelopmental and neurodegenerative disorders in a targeted way," said Arnold Kriegstein, MD, PhD, director of the Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research at UCSF and co-lead author on the paper.

The researchers generated and transplanted a type of human nerve-cell progenitor called the medial ganglionic eminence (MGE) cell, in experiments described in the May 2 edition of Cell Stem Cell. Development of these human MGE cells within the mouse brain mimics what occurs in human development, they said.

Kriegstein sees MGE cells as a potential treatment to better control nerve circuits that become overactive in certain neurological disorders. Unlike other neural stem cells that can form many cell types -- and that may potentially be less controllable as a consequence -- most MGE cells are restricted to producing a type of cell called an interneuron. Interneurons integrate into the brain and provide controlled inhibition to balance the activity of nerve circuits.

To generate MGE cells in the lab, the researchers reliably directed the differentiation of human pluripotent stem cells -- either human embryonic stem cells or induced pluripotent stem cells derived from human skin. These two kinds of stem cells have virtually unlimited potential to become any human cell type. When transplanted into a strain of mice that does not reject human tissue, the human MGE-like cells survived within the rodent forebrain, integrated into the brain by forming connections with rodent nerve cells, and matured into specialized subtypes of interneurons.

These findings may serve as a model to study human diseases in which mature interneurons malfunction, according to Kriegstein. The researchers' methods may also be used to generate vast numbers of human MGE cells in quantities sufficient to launch potential future clinical trials, he said.

Kriegstein was a co-leader of the research, along with Arturo Alvarez-Buylla, PhD, UCSF professor of neurological surgery; John Rubenstein, MD, PhD, UCSF professor of psychiatry; and UCSF postdoctoral scholars Cory Nicholas, PhD, and Jiadong Chen, PhD.

Nicholas utilized key growth factors and other molecules to direct the derivation and maturation of the human MGE-like interneurons. He timed the delivery of these factors to shape their developmental path and confirmed their progression along this path. Chen used electrical measurements to carefully study the physiological and firing properties of the interneurons, as well as the formation of synapses between neurons.

Previously, UCSF researchers led by Allan Basbaum, PhD, chair of anatomy at UCSF, have used mouse MGE cell transplantation into the mouse spinal cord to reduce neuropathic pain, a surprising application outside the brain. Kriegstein, Nicholas and colleagues now are exploring the use of human MGE cells in mouse models of neuropathic pain and spasticity, Parkinson's disease and epilepsy.

"The hope is that we can deliver these cells to various places within the nervous system that have been overactive and that they will functionally integrate and provide regulated inhibition," Nicholas said.

The researchers also plan to develop MGE cells from induced pluripotent stem cells derived from skin cells of individuals with autism, epilepsy, schizophrenia and Alzheimer's disease, in order to investigate how the development and function of interneurons might become abnormal -- creating a lab-dish model of disease.

One mystery and challenge to both the clinical and pre-clinical study of human MGE cells is that they develop at a slower, human pace, reflecting an "intrinsic clock." In fast-developing mice, the human MGE-like cells still took seven to nine months to form interneuron subtypes that normally are present near birth.

"If we could accelerate the clock in human cells, then that would be very encouraging for various applications," Kriegstein said.

Other UCSF co-authors of the Cell Stem Cell study include Yunshuo Caroline Tang, a MD/PhD student; research specialists Nadine Chalmers and Christine Arnold; and UCSF postdoctoral fellows Daniel Vogt, PhD, and Ying-Jiun Chen, PhD.

Additional co-authors are Stanford University neurosurgery resident Derek Southwell, MD, PhD; Monash University professors of immunology and stem cell research Edouard Stanley, PhD, and Andrew Elefanty, PhD; and Yoshiki Sasai, PhD, from the RIKEN Center for Developmental Biology.

The research was funded by the California Institute of Regenerative Medicine, the National Institutes of Health, and the Osher Foundation. Arnold Kriegstein, Arturo Alvarez-Buylla, John Rubenstein, and Cory Nicholas are co-founders and shareholders of Neurona Therapeutics. An application for a patent, "In Vitro Production of Medial Ganglionic Eminence Precursor Cells," has been filed.

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Story Source:

The above story is reprinted from materials provided by University of California, San Francisco (UCSF), via Newswise.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Cory?R. Nicholas, Jiadong Chen, Yunshuo Tang, Derek?G. Southwell, Nadine Chalmers, Daniel Vogt, Christine?M. Arnold, Ying-Jiun?J. Chen, Edouard?G. Stanley, Andrew?G. Elefanty, Yoshiki Sasai, Arturo Alvarez-Buylla, John?L.R. Rubenstein, Arnold?R. Kriegstein. Functional Maturation of hPSC-Derived Forebrain Interneurons Requires an Extended Timeline and Mimics Human Neural Development. Cell Stem Cell, 2013; 12 (5): 573 DOI: 10.1016/j.stem.2013.04.005

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/P711yUt8JeY/130503230313.htm

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Friday, May 3, 2013

Chael Sonnen not retiring, eyes Wanderlei Silva

Chael Sonnen's loss to Jon Jones at UFC 159 put his career in question. At 36 years old, and with title losses in two different divisions, would Sonnen consider retiring? He answered that question on Fuel's "UFC Tonight," and that answer is no.

"I have a lot of goals I want to achieve still, and retirement won't help me get that done," Sonnen said.

He said the weight class is up for debate, though he liked the switch to light heavyweight after years as a middleweight. He would also be happy to fight at a catchweight, like Rich Franklin did for a few fights when moving up in weight. But there's no question about who he wants to fight.

"I'm not going anywhere until me and Wanderlei [Silva] straighten this thing out once and for all,"

Like Sonnen, Silva has moved between middleweight, light heavyweight and catchweights somewhere between. He is also 36, but the sensible match-up isn't why Sonnen is interested in this bout. Sonnen has a problem with this video from 2010:

Here is how Sonnen viewed this video.

"Wanderlei pulled a really dirtbag move on me one time. We're in a van, he mutters something at me, I can't understand what he's saying. He then puts it on YouTube with subtitles because he knows I can't understand him. He puts in these subtitles and I don't know if it's what he's said or not. Essentially, he tells me off, and it looks as though I'm conceding to him. That doesn't fly. If he calls you out, whether it's in a van or not, if you're a fighter, you must respond. I'm ready to respond."

Silva responded by tweeting this:

And then sharing the above video and saying, "Real men talk face to face."

Is this a fight you want to see, Cagereaders? Speak up on Facebook or Twitter.

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Source: http://sports.yahoo.com/blogs/mma-cagewriter/chael-sonnen-not-retiring-eyes-wanderlei-silva-182102684.html

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Tuesday, April 30, 2013

UK mortgage approvals rise more than expected in March

LONDON (Reuters) - British mortgage approvals for house purchase bounced back more strongly than expected in March, in a further sign homebuyers are benefiting from the central bank's flagship credit scheme.

Lending to businesses fell last month, but at a slower pace than in February, Bank of England data showed on Tuesday.

The central bank has been hoping that its Funding for Lending Scheme (FLS), opened in August and revamped last week, will boost the flow of credit to households and businesses, thus easing what it sees as a major drag on the economy.

Mortgage approvals numbered 53,504 in March, up from 51,947 in February and a thousand more than analysts had forecast.

Before the 2008 financial crisis, monthly mortgage approvals ran at around 90,000, but the number of home sales has slumped since then and is only slowly starting to recover.

Lending to non-financial businesses shrank for a second straight month, by a net 0.6 billion pounds. Within that, lending to smaller firms dropped by 0.1 billion pounds, erasing the previous month's gain.

Last week the central bank and the finance ministry retooled the FLS, giving banks greater incentives to lend to small and medium-sized firms which complain they are starved of credit.

The BoE's preferred gauge of money supply, M4 excluding intermediate other financial corporations, rose 0.3 percent, taking the annual growth rate to 4.5 percent.

(Reporting by Olesya Dmitracova and Christina Fincher)

Source: http://news.yahoo.com/uk-mortgage-approvals-rise-more-expected-march-083137038.html

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