UK mortgage approvals rise more than expected in March

LONDON (Reuters) - British mortgage approvals for house purchase bounced back more strongly than expected in March, in a further sign homebuyers are benefiting from the central bank's flagship credit scheme.

Lending to businesses fell last month, but at a slower pace than in February, Bank of England data showed on Tuesday.

The central bank has been hoping that its Funding for Lending Scheme (FLS), opened in August and revamped last week, will boost the flow of credit to households and businesses, thus easing what it sees as a major drag on the economy.

Mortgage approvals numbered 53,504 in March, up from 51,947 in February and a thousand more than analysts had forecast.

Before the 2008 financial crisis, monthly mortgage approvals ran at around 90,000, but the number of home sales has slumped since then and is only slowly starting to recover.

Lending to non-financial businesses shrank for a second straight month, by a net 0.6 billion pounds. Within that, lending to smaller firms dropped by 0.1 billion pounds, erasing the previous month's gain.

Last week the central bank and the finance ministry retooled the FLS, giving banks greater incentives to lend to small and medium-sized firms which complain they are starved of credit.

The BoE's preferred gauge of money supply, M4 excluding intermediate other financial corporations, rose 0.3 percent, taking the annual growth rate to 4.5 percent.

(Reporting by Olesya Dmitracova and Christina Fincher)

Source: http://news.yahoo.com/uk-mortgage-approvals-rise-more-expected-march-083137038.html

gi joe jason wu for target collection nick diaz vs carlos condit the patriot hall of fame occupy dc ufc 143 fight card

New conservative lobbying push for gay marriage

ST. PAUL, Minn. (AP) ? A national group of prominent GOP donors that supports gay marriage is pouring new money into lobbying efforts to get Republican lawmakers to vote to make it legal.

American Unity PAC was formed last year to lend financial support to Republicans who bucked the party's longstanding opposition to gay marriage. Its founders are launching a new lobbying organization, American Unity Fund, and already have spent more than $250,000 in Minnesota, where the Legislature could vote on the issue as early as next week.

The group has spent $500,000 on lobbying since last month, including efforts in Rhode Island, Delaware, Indiana, West Virginia and Utah.

Billionaire hedge fund manager and Republican donor Paul Singer launched American Unity PAC. The lobbying effort is the next phase as the push for gay marriage spreads to more states, spokesman Jeff Cook-McCormac told The Associated Press.

"What you have is this network of influential Republicans who really want to see the party embrace the freedom to marry, and believe it's not only the right thing for the country but also good politics," Cook-McCormac said.

In Minnesota, the money has gone to state groups that are lobbying Republican lawmakers and for polling on gay marriage in a handful of suburban districts held by Republicans. So far, only one Minnesota Republican lawmaker has committed to voting to legalize gay marriage: Sen. Branden Petersen, of Andover.

"I think there will be some more. There are legislators out there that are struggling with this," said Carl Kuhl, a former political aide to former GOP Sen. Norm Coleman and Republican gubernatorial candidate Tom Emmer. Kuhl's public affairs firm is contracted by Minnesotans United, the lead lobby group for gay marriage in Minnesota and main recipient of American Unity's Minnesota spending.

Gay marriage's fate in Minnesota may rest with the House, where support is seen as shakier than in the Senate. A handful of votes from Republicans could put it over the top. Nearly two dozen House Republicans represent more socially moderate suburbs and might be candidates to vote yes.

House Speaker Paul Thissen, DFL-Minneapolis, said he has encouraged advocates of the marriage bill to round up Republican votes, if nothing else than to send a message to Minnesota residents that it's not a partisan proposition. But that will be politically risky; the main opposition group to same-sex marriage, Minnesota for Marriage, has said it will seek consequences for Republicans who stray on gay marriage.

Part of American Unity PAC's original mission was to spend money on behalf of Republican gay marriage supporters. Many GOP lawmakers have faced primary challenges funded in part by anti-gay marriage groups such as the National Organization for Marriage, which argue that the lawmakers had betrayed the party's core principles.

Since forming the lobby group last month, American Unity also spent money to win over Republican lawmakers in Rhode Island, where last week all five Republicans in the state Senate jumped on the gay marriage bandwagon. Rhode Island is on track to legalize gay marriage by next week, which would make it the 11th U.S. state where gay marriage is legal.

There are also plans to lobby federal lawmakers on gay rights issues.

"We intend to work on this effort until every American citizen is treated equally under the law," Cook-McCormac said. Other wealthy, traditionally Republican donors giving money to the group include Seth Klarman, David Herro and Cliff Asness.

Though only one current GOP officeholder in Minnesota is on record supporting gay marriage, a handful of prominent Republicans have spoken out in favor of it. They include former state auditor Pat Anderson and Brian McClung, who was spokesman for former Gov. Tim Pawlenty. Prominent Republican donors including former politician Wheelock Whitney and businesswoman Marilyn Carlson Nelson have also lent support and donated money.

Since it first formed to campaign against last fall's gay marriage ban and then shifted to pushing for its legalization at the Capitol, Minnesotans United has been building Republican alliances, hiring multiple lobbyists with Republican ties.

Source: http://news.yahoo.com/conservative-lobbying-push-gay-marriage-050802280.html

josh smith presidents day mindy mccready mindy mccready downton abbey nba all star game danica patrick

92% Jurassic Park: An IMAX 3D Experience

All Critics (96) | Top Critics (24) | Fresh (97) | Rotten (8) | DVD (39)

The enthralling man-vs.-nature parable based on the late Michael Crichton's best-selling novel hasn't aged one bit.

The 3-D process adds not just dimension but depth - a technological extension of cinematographer Gregg Toland's deep-focus innovations in The Grapes of Wrath and Citizen Kane. The change in perspective creates greater intensity.

I'm a fan of this movie. It is thrilling, and the 3-D treatment is a nice enhancement.

This movie doesn't just stand the test of time, it transcends it.

"Jurassic Park" remains an absolute thrill from a Spielberg in top form: Funny, scary, fast-moving and full of just-right details.

"Jurassic Park" was impressive in 1993. Twenty years later, it's flawless.

A classic gets even better.

Steven Spielbeg's 1993 tale of an island plagued dinosaurs running amok holds up surprisingly well in the special effects category.

The film is a classic and the chance to see it on the big screen again (or for the first time) should not be missed

Sentiment is explained by science as the family impulse that motivates so many Steven Spielberg stories is revealed to be an evolutionary imperative in this near-perfect action-adventure.

[Looks] better not only than effects-driven movies of the same period, but better, frankly, than half of what gets released nowadays.

Kids who love dinosaurs will love it. And who doesn't?

confirms both Spielberg's mastery of cinematic thrills and the comparatively empty bombast of today's summer tentpole movies, even the better ones.

Jurassic Park shows us a director in transition, and the film captures his transformation in its own kind of cinematic amber.

[The] 3D [conversion] provides the definitive version of this classic film. Jurassic Park has been transformed with with artistry, nuance and sophistication, and it's an absolute must-see during this brief run.

The 3D effects had me nearly jumping out of my seat. Some say Hollywood is converting too many old films to 3D. But, "Jurassic Park" was the perfect choice. There's nothing more fun than sharing a seat with a snapping dinosaur.

Spielberg treats us as he does his characters, leading us into a strange land and expecting us to make it out with all our faculties intact; it's a tall order, given the heart-stopping, bloodcurdling, limbs-numbing excitement packed into the second hour.

It is as if time has passed the movie by. "Jurassic Park" remains solid entertainment, but the awe and wonder have faded.

The thrill of seeing live dinosaurs on screen is not as acute today as it was 20 years ago admittedly, but there is still some 3D awe left in the creations that roared 65 billion years ago...

The 3D isn't pushed on the audience, but it does reveal the amount of depth that Spielberg actually put into the film 20 years ago.

While it's not the most profound of Spielberg's works or the most entertaining from a popcorn perspective, it's one of the most technically flawless movies he's ever produced.

Jurassic Park 3D is like being reunited with an old friend; an old friend that wants to eat you and maul you to death, but still. A classic is reborn in glorious IMAX with a vibrantly stunning use of 3D.

If releasing the film in 3-D is the only way to get it back in theaters, then the gimmick is an acceptable addition. The 3-D is good. But when a movie is this near flawless, nothing is needed to make it better.

The 3D conversion ruins everything, like the comet that killed the dinosaurs, making Jurassic Park the rare amusement I'd prefer to revisit at home.

A beast of a movie is gifted a superfluous-but-superb rouging of the cheeks, offering fanatics something new to study while newcomers will be ruined for any future television airings.

Source: http://www.rottentomatoes.com/m/jurassic_park_an_imax_3d_experience_1993/

taylor allderdice vincent jackson vicki gunvalson pierre garcon brown recluse spider wiz khalifa taylor allderdice eddie royal

Moody's, S&P settle lawsuits over SIV investments

It's generally understood that in the Fox News and Glenn Beck breakup, Fox was the dumper and Beck the dumpee. But, in most breakups where the couple shares a social circle, neither party wants a reputation as the dumpee. Beck says he's the one who wanted to leave -- because the network was so depressing. "I remember feeling, 'If you do not leave now, you won?t leave with your soul intact,'" Beck said Friday, according to Forbes' Jeff Bercovici. Roger Ailes tried to talk him out of it. "Roger said to me, 'You're not going to leave.' And I said, 'I am. ...

Source: http://news.yahoo.com/moodys-p-settle-lawsuits-over-siv-investments-230711902.html

Lupe Ontiveros London 2012 China muhammad ali Opening ceremony London 2012 Olympics Schedule 2012 Olympic Medal Count 2012 Olympics 2012

Google Brings Its New And Improved File Viewer For MS Office Documents To Chrome Beta

If you regularly need to open Microsoft Office documents in the browser, Google now offers you a new Chrome extension that renders Word, Excel and PowerPoint files directly in the browser. Currently, these documents open in a Drive-based viewer, but after you install the new Chrome Office Viewer (which is officially still in beta), these documents will open directly in the browser. Until now, this feature was limited to Chromebooks, but now it’s also available for Chrome on Windows and Mac. You do need to run Chrome Beta, however, as it’s not available for the stable release channel of Chrome just yet. The advantage of this new plug-in (which weighs in at over 20 megabytes), Google says, is that it ensures that you are protected from malware because the files open in a specialized sandbox “to impede attackers who use compromised Office files to try to steal private information or monitor your activities.” While Google doesn’t say so in today’s announcement, chances are this new feature is at least partially powered by the technology it acquired when it bought Quickoffice last year. When Google launched the Pixel Chromebook in February, it also said it would port Quickoffice to Chrome, using its Native Client technology. Those three months are almost over, so we’ll likely see a bit more from Google with regard to Office documents in the browser.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/2UTTJYJG7Zs/

dj am bully bohemian rhapsody bohemian rhapsody spike lee carson daly heejun han

Richard Bausch wins $30,000 story prize

NEW YORK (AP) ? One of the country's top short story writers has won a $30,000 prize.

Richard Bausch, author of eight story collections and winner of numerous other honors, is this year's recipient of the Rea Award for the Short Story.

The prize, announced Thursday, is given for making a "significant contribution" to the art of short story writing. Bausch's books include "Something is Out There" and "Someone to Watch Over Me." He also has written 11 novels and has been praised for his lyrical style and his insights into a wide a range of people and emotions.

The Rea Award was established in 1986. Previous winners include Eudora Welty, John Updike and Lorrie Moore.

Source: http://news.yahoo.com/richard-bausch-wins-30-000-story-prize-133557183.html

Lolo Jones Marvin Hamlisch Megan Rossee grenada grenada Sikh Sanya Richards Ross

Key cellular organelle involved in gene silencing identified

Apr. 25, 2013 ? RNA molecules, made from DNA, are best known for their role in protein production. MicroRNAs (miRNAs), however, are short (~22) nucleotide RNA sequences found in plants and animals that do not encode proteins but act in gene regulation and, in the process, impact almost all biological processes -- from development to physiology to stress response.

Present in almost in every cell, microRNAs are known to target tens to hundreds of genes each and to be able to repress, or "silence," their expression. What is less well understood is how exactly miRNAs repress target gene expression.

Now a team of scientists led by geneticists at the University of California, Riverside has conducted a study on plants (Arabidopsis) that shows that the site of action of the repression of target gene expression occurs on the endoplasmic reticulum (ER), a cellular organelle that is an interconnected network of membranes -- essentially, flattened sacs and branching tubules -- that extends like a flat balloon throughout the cytoplasm in plant and animal cells.

"Our study is the first to demonstrate that the ER is where miRNA-mediated translation repression occurs," said lead researcher Xuemei Chen, a professor of plant cell and molecular biology and a Howard Hughes Medical Institute-Gordon and Betty Moore Foundation Investigator. "To understand how microRNAs repress target gene expression, we first need to know where microRNAs act in the cell. Until now no one knew that membranes are essential for microRNA activity. Our work shows that an integral membrane protein, AMP1, is required for the miRNA-mediated target gene repression to be successful. As AMP1 has counterparts in animals, our findings in plants could have broader implications."

Study results appear today in the journal Cell.

Simply put, DNA makes RNA, and then RNA makes proteins. Specifically, RNA encodes genetic information that can be "translated" into the amino acid sequence of proteins. But noncoding RNAs -- RNAs that do not encode proteins -- are increasingly found to act in numerous biological processes. MicroRNAs are a class of noncoding RNAs whose main function is to downregulate gene expression.

Research on miRNAs has increased tremendously since they were first identified about 20 years ago. In the case of diseases, if some genes are up- or down-regulated, miRNAs can be used to change the expression of these genes to fight the diseases, thus showing therapeutic potential.

MicroRNAs are known to regulate target genes by two major modes of action: they either destabilize the target RNAs, leading to their degradation, or they do not impact the stability of the target RNAs, but simply prevent them from being translated into proteins -- a process known as translation inhibition. The end result of translation inhibition is that the genes do not get expressed. Just how miRNAs cause translational inhibition of their target genes is not well understood.

"We were surprised that the ER is required for the translational inhibition activity of miRNAs," Chen said. "This new knowledge will expedite our understanding of the mechanism of gene silencing. Basically, now we know where to look: the ER. We also suspect it is the rough ER portions that are involved."

Chen explained that the ER has two types: rough and smooth. Rough ER, which synthesizes and packages proteins, looks bumpy; smooth ER, which acts in lipid synthesis and protein secretion, resembles tubes. The ER protein AMP1, she said, is anchored in the rough ER.

"My lab has been conducting research on AMP1 for many years," she said. "And it's this protein that drew our attention to the ER. First, we realized that AMP1 is involved in miRNA-mediated translational inhibition. Then, since we already knew that AMP1 is localized in the rough ER, we shifted our focus to this organelle."

Next, her lab will attempt to crack the mechanism of miRNA-mediated translational inhibition. They will investigate, too, how miRNAs are recruited to the ER.

Chen was joined in the study by Shengben Li (first author of the research paper), Lin Liu, Xigang Liu, Yu Yu, Lijuan Ji and Natasha Raikhel at UC Riverside; Xiaohong Zhuang and Liwen Jiang at the Chinese University of Hong Kong; Xia Cui and Xiaofeng Cao at the Chinese Avademy of Sciences, Beijing; Zhiqiang Pan at the University of Mississippi; Beixin Mo at Shenzhen University, China; and Fuchun Zhang at Xinjiang University, China.

The study was supported by grants to Chen from the National Institutes of Health, the National Science Foundation, and the Howard Hughes Medical Institute and Gordon and Betty Moore Foundation.

Share this story on Facebook, Twitter, and Google:

Other social bookmarking and sharing tools:

---

Story Source:

The above story is reprinted from materials provided by University of California - Riverside. The original article was written by Iqbal Pittalwala.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

---

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/hP4uiZtvpTo/130425132656.htm

Presidents Day 2013 jack white wiz khalifa 2013 Grammys kelly clarkson Lumineers The Lumineers